How does coronavirus kill? Clinicians trace a ferocious rampage through the body, from brain to toes
As the number of confirmed cases of COVID-19 surges past 2.2 million globally and deaths surpass 150,000, clinicians and pathologists are struggling to understand the damage wrought by the coronavirus as it tears through the body. They are realizing that although the lungs are ground zero, its reach can extend to many organs including the heart and blood vessels, kidneys, gut, and brain. “[The disease] can attack almost anything in the body with devastating consequences,” says cardiologist Harlan Krumholz of Yale University and Yale-New Haven Hospital, who is leading multiple efforts to gather clinical data on COVID-19. “Its ferocity is breathtaking and humbling.”Unusual Presentations of COVID-19: 'Our Ignorance Is Profound'
Although a cause-and-effect relationship is unknown, people with the virus have presented with or developed heart disease, acute liver injury, ongoing GI issues, skin manifestations, neurologic damage, and other problems, especially among sicker people. For example, French physicians described an association with encephalopathy, agitation, confusion, and corticospinal tract signs among 58 people hospitalized with acute respiratory distress. Strange new coronavirus symptoms have been uncovered The novel coronavirus has a few common symptoms that can be very misleading. Fever, cough, fatigue, and muscle pain are also typical of the common cold or flu, as are chills, shaking, headache, and sore throat. Shortness of breath can also appear, and breathing issues are common for other ailments. But doctors who have observed COVID-19 patients have been able to identify a slew of other symptoms that might be indicative of a SARS-CoV-2 infection.